Stimuli-Responsive Nanozyme Reprograms Tumor Immunometabolism in Liver Cancer 標靶肝癌的奈米酶
- Becky Chen
- Feb 10
- 1 min read
Updated: Feb 14
We developed a pH-responsive lipid–gelatin–protamine nanozyme that delivers glucose oxidase to hepatocellular carcinoma, selectively depleting intratumoral glucose and inducing oxidative stress. This metabolic reprogramming sensitizes tumors to apoptosis, promotes immunogenic cell death, and enhances antitumor immunity. When combined with doxorubicin and PD-1 checkpoint blockade, the nanozyme overcomes therapeutic resistance and achieves durable tumor control in orthotopic HCC models.
癌細胞需要大量葡萄糖來快速生長，我們開發了一種能感應腫瘤微環境的「智慧型奈米酶」，能專一性的把GOx酵素送進肝腫瘤內，消耗腫瘤裡的葡萄糖，讓癌細胞陷入能量危機。同時，它會產生氧化壓力，讓癌細胞更容易死亡，並釋放出能喚醒免疫系統的訊號。奈米酶不只直接攻擊癌細胞，還能幫助免疫細胞更有效地辨認並清除腫瘤。當這個奈米酶和化療藥物以及免疫檢查點治療一起使用時，在肝癌模型中成功克服治療抗性，達到長期抑制腫瘤的效果。我們的目標，是從「改變癌細胞的能量來源」開始，讓免疫系統重新取得主導權。
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