Yunching Chen (Becky) Chen

Yen-Nhi Ngoc Ta, Thu-Thuy Can, Van-Anh Thi Nguyen, Meng-Cheng Hsieh, Bang Giang Thi Cao, Dehui Wan, Chian-Hui Lai, Chun-Chieh Wu, Fu-Fei Hsu, Yu-Ting Yen*, Shen-Nien Wang* & Yunching Chen* (2026) Stimuli-Responsive Nanozyme Reprograms Tumor Immunometabolism and Overcomes Therapeutic Resistance in Hepatocellular Carcinoma. ACS Nano 20(2):1870-1884. 

Ling-Chu Yang, Ching-Wen Hwang, Shao-Hsuan Tsao, Hsin-Yao Lin*, Yunching Chen*, Dehui Wan* (2026) Injectable near-infrared–responsive silk fibroin nanocomposite hydrogel enabling spatiotemporally controlled photothermal chemotherapy. Chemical Engineering Journal 529: 173044

Hsi-Chien Huang, Yi-Ju Chen, Mei-Wei Lin, Chih-I Huang, Chia-Yueh Hsiung, Sheng Yang, Yi-Yu Ke, Yu-Ting Yen, Hsin-Tzu Hsieh, Yen-Fei Lu, Yun-Chieh Sung, Fu-Fei Hsu, Anthony Yan-Tang Wu, Charles Pin-Kuang Lai, Jane Wang, Min-Yuan Chou, Chung-Pin Li*, Shu-Yi Lin*, Yunching Chen* (2025) Stroma-Targeted Gene Delivery for Efficient Immunogene Therapy against Pancreatic Cancer. Mol Ther 1525-0016(25)00813-5.

Putry Yosefa Siboro, Nhien Nguyen, Shih-Kai Lo, Fwu-Long Mi, Wen-Wei Wu, Che-Hung Wang, Yun-Ching Chen, Wei-Lun Pan, Sheng-Yao Peng, Lam-Duc-Huy Nguyen, Kun-Ju Lin, Hsing-Wen Sung (2025) Innate Immunity-Guided Macrophage-Homing Nanoplatform for Oral Tumor Immunotherapy and Real-Time Deep-Tissue Imaging in Pre-Clinical Models. Adv Mater 37(40):e07607.

Sheng Yang, Yen-Nhi Ngoc Ta, Yunching Chen* (2025) Nanotechnology-enhanced immunotherapies for pancreatic ductal adenocarcinoma: challenges and opportunities. Drug Deliv Transl Res 15(11):4067-4097.

Lam-Duc-Huy Nguyen, Sheng-Liang Cheng, Yu-Ting Yen, Hsin-Mei Lee, Te-Haw Wu, Jane Wang,* Shu-Yi Lin*, Yunching Chen* (2025) A Cryogel-Based Dendritic Cell Vaccine for Post-Surgical Breast Cancer Immunotherapy. Advanced Science e03238.

Y. Chen, Y. Su, S. R. Roffler* (2025) Overcoming polyethylene glycol immune hurdles for effective and safe nanomedicines. Nature Reviews Bioengineering, 1-19.

V. Chan, H.-M. Lee, H. Takata, S.-L. Cheng, Y.-T. Yen, L. Pfeifer, L. Rushton, P.-H. Chao, F. Zhao, C. Y. Ong, N. Al‐Fayez, T. Ishida, Y. Chen*, S.-D. Li* (2025) Imiquimod‐Loaded Phospholipid‐Free Small Unilamellar Vesicles Activate the Tumor Immune Microenvironment to Treat Liver Cancer and Liver Metastases. Advanced Healthcare Materials, 2501691.

Sheng-Liang Cheng, Chien-Huang Wu, Yun-Jen Tsai, Jen-Shin Song, Hsin-Min Chen, Teng-Kuang Yeh, Chia-Tung Shen, Jou-Chien Chiang, Hsin-Mei Lee, Kuan-Wei Huang, Yuling Chen, J Timothy Qiu, Yu-Ting Yen*, Kak-Shan Shia*, Yunching Chen* (2025) CXCR4 antagonist-loaded nanoparticles reprogram the tumor microenvironment and enhance immunotherapy in hepatocellular carcinoma. J Control Release 379:967-981.

Sheng-Liang Cheng, Hsin-Mei Lee, Chung-Pin Li, Mei-Wei Lin, Min-Yuan Chou, Yu-Ting Yen, Tun-Han Wu, Yun-Chen Lian, Yu-Chuan Shih, Chi-Shiun Chiang, Ting-Wen Chen*, Dehui Wan*, Yunching Chen* (2024) Robust and Sustained STING Activation via Hydrogel-Based In-Situ Vaccination for Cancer Immunotherapy. ACS Nano 18(43):29439-29456. 

Ya-Han Chuang, Yueh-Feng Wu, Ya-Hui Lin, Yin-Hsu Chen, Yu-Xian Zhou, Shao-Chun Hsu, Hsin-Mei Lee, Ann-Shyn Chiang, Yunching Chen, Shiang-Jiuun Chen, Sung-Jan Lin, Li-An Chu. (2024) Super‐Resolution Imaging in Collagen‐Abundant Thick Tissues. Small Structures 2400231.

Hui-Teng Cheng, Yen-Nhi Ngoc Ta, Tiffaney Hsia, Yunching Chen* (2024) A Quantitative Review of Nanotechnology-Based Therapeutics for Kidney Diseases. WIREs Nanomedicine & Nanobiotechnology 16(2):e1953.

Tiffaney Hsia, Yunching Chen* (2024) RNA-encapsulating Lipid Nanoparticles in Cancer Immunotherapy: From Pre-Clinical Studies to Clinical Trials. European Journal of Pharmaceutics and Biopharmaceutics 197:114234.

Hsuan-Yu Mu, Chiao-Min Lin, Li-An Chu, Ya-Hui Lin, Ji Li, Chao-Yu Liu, His-Chien Huang, Sheng-Liang Cheng, Tsung-Ying Lee, Hsin-Mei Lee, Hsin-Min Chen, Yun-Jen Tsai, Yunching Chen*, Jen-Huang Huang* (2024) Ex Vivo Evaluation of Combination Immunotherapy Using Tumor-Microenvironment-on-Chip. Advanced Healthcare Materials 13(2), 2302268.

Hsuan‐Yu Mu, Yen-Nhi Ngoc Ta, Max Jing Rui Tham, Fu-Fei Hsu, Yu-Chieh Lin, Hsi-Chien Huang, Yun-Chieh Sung, Chih-I Huang, Ching-Ling Wu, Chao-Hung Chang, Sheng Yang, Tsung-Ying Lee, Dehui Wan, Jane Wang, Dan G. Duda, Yves Boucher, Jen-Huang Huang*, Wee Han Ang*, Yunching Chen* (2024) A chemoimmunotherapy nanogel enables efficient delivery of interleukin-2 and induction of immunogenic cell death for effective cancer therapy. Advanced Functional Materials 34 (1), 2303033

Yunching Chen* (2023) Nanotechnology for next-generation cancer immunotherapy: State of the art and future perspectives. Journal of Controlled Release 28;356:14-25.

Tsung-Ying Lee, Hung-Hsun Lu, Hui-Teng Cheng, Hsi-Chien Huang, Yun-Jen Tsai, I-Hsiang Chang, Chao-Peng Tu, Chieh-Wei Chung, Tsai-Te Lu*, Chi-How Peng*, Yunching Chen* (2023) Delivery of Nitric Oxide with a pH-Responsive Nanocarrier for the Treatment of Renal Fibrosis. Journal of Controlled Release 354, 417-428

Bryan John Abel Magoling, Anthony Yan‐Tang Wu, Yen‐Ju Chen, Wendy Wan‐Ting Wong, Steven Ting‐Yu Chuo, Hsi‐Chien Huang, Yun‐Chieh Sung, Hsin Tzu Hsieh, Poya Huang, Kang‐Zhang Lee, Kuan‐Wei Huang, Ruey‐Hwa Chen, Yunching Chen, Charles Pin‐Kuang Lai* (2023) Membrane Protein Modification Modulates Big and Small Extracellular Vesicle Biodistribution and Tumorigenic Potential in Breast Cancers In Vivo. Advanced Materials, 35(13):e2208966.

Hsin-Tzu Hsieh, Hsi-Chien Huang, Chieh-Wei Chung, Cheng-Chin Chiang, Tiffaney Hsia, Hsin-Fang Wu, Rui-Lin Huang, Chi-Shiun Chiang, Jane Wang, Tsai-Te Lu*, Yunching Chen* (2022) CXCR4-Targeted Nitric Oxide Nanoparticles Deliver PD-L1 siRNA for Immunotherapy against Glioblastoma. Journal of Controlled Release 14;352:920-930

Hsi-Chien Huang, Yun-Chieh Sung, Chung-Pin Li, Dehui Wan, Po-Han Chao, Bo-Wen Liao, Hui-Teng Cheng, Fu-Fei Hsu, Chieh-Cheng Huang, Yu-Hui Liao, Hsin Tzu Hsieh, Yu-Chuan Shih, I-Ju Liu, Han-Chung Wu, Tsai-Te Lu*, Jane Wang*, Yunching Chen* (2022) Reversal of Pancreatic Desmoplasia by a Tumor Stroma-targeted Nitric Oxide Nanogel Overcomes TRAIL Resistance in Pancreatic Tumors. Gut 71 (9), 1843-1855

Hung-Hsun Lu, Hsueh Wen Liu, Trinh Kieu Dinh, Cheng-Hung Huang, Hsi-Chien Huang, Ya-Ching Tseng, Man-Hsuan Ku, Fu-Sheng Wang, Yunching Chen* and Chi-How Peng* (2022) pH-Responsive, two-in-one doxorubicin and Bcl-2 siRNA-loaded micelleplexes for triple-negative breast cancer therapy. Polym. Chem. 2022,13, 5568-5578

Jai-Shin Liu, Wei-Kai Fang, Shan-Min Yang, Meng-Chen Wu, Tsan-Jan Chen, Chih-Ming Chen, Tung-Yueh Lin, Kai-Lun Liu, Chien-Ming Wu, Yun-Ching Chen, Chih-Pin Chuu, Ling-Yu Wang, Hsing-Pang Hsieh, Hsing-Jien Kung, Wen-Ching Wang (2022) Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer. Journal of biomedical science 2022, 29, 29

Hui-Teng Cheng, Yun-Chieh Sung, Hsi-Chien Huang, Tsung-Ying Lee, Yu-Hui Liao, Yi-Hua Sheng, Pei-Ru Jin, Kuan-Wei Huang, Ling-Hsuan Chen, Yi-Ting Chen, Zi-Yan Liu, Tzu-Chieh Lin, Hsueh-Cheng Wang, Cheng-Han Chao, I Pu Juang, Chi-Ting Su, Kuo-How Huang, Shuei-Liong Lin, Jane Wang, Yunching Chen* (2022) Delivery of Sorafenib by Myofibroblast-targeted Nanoparticles for the Treatment of Renal Fibrosis. Journal of Controlled Release 2022, 346:169-179 

Pei-Hsuan Hsieh, Huan-Chih Wang, Hsi-Chin Wu, Lu-Chieh Huang, Shao-Chi Chen, Ting-Yun Shiue, Yunching Chen, Tzu-Wei Wang* (2022) Dual-responsive Polypeptide Nanoparticles Attenuate Tumor-associated Stromal Desmoplasia through Programming Dissociation. Biomaterials 2022, 284:121469 

Yong-Huei Hong, Manmath Narwane, Lawrence Yu-Min Liu, Yi-Da Huang, Chieh-Wei Chung, Yi-Hong Chen, Bo-Wen Liao, Yu-Hsiang Chang, Cheng-Ru Wu, Hsi-Chien Huang, I-Jui Hsu, Ling-Yun Cheng, Liang-Yi Wu, Yu-Lun Chueh, Yunching Chen, Chia-Her Lin, and Tsai-Te Lu* (2022) Enhanced Oral NO Delivery through Bioinorganic Engineering of Acid-Sensitive Prodrug into a Transformer-like DNIC@MOF Microrod. ACS Appl. Mater. Interfaces 2022, 14, 3, 3849–3863 

Cheng-Yun Wu, Yu-Hsuan Hsu, Yunching Chen, Ling-Chu Yang, Shao-Chin Tseng, Wan-Ru Chen, Chieh-Cheng Huang, Dehui Wan (2021) Robust O 2 Supplementation from a Trimetallic Nanozyme-Based Self-Sufficient Complementary System Synergistically Enhances the Starvation/Photothermal Therapy against Hypoxic Tumors. ACS Appl. Mater. Interfaces, 13, 32, 38090-38104. 

Venkanagouda S Goudar, Manohar Prasad Koduri, Yen-Nhi Ngoc Ta, Yunching Chen, Li-An Chu, Long-Sheng Lu, Fan-Gang Tseng (2021) Impact of a Desmoplastic Tumor Microenvironment for Colon Cancer Drug Sensitivity: A Study with 3D Chimeric Tumor Spheroids. ACS Appl. Mater. Interfaces, 13, 41, 48478-48491. 

Pei-Ru Jin, Yen-Nhi Ngoc Ta, Yan-Ning Yu, Hsin Tzu Hsieh, Shang-Ying Hsieh, Tiffaney Hsia, Hao Liu, Chan-Wei Hsu, Jeng-Liang Han*, Yunching Chen* (2021) A Cinchona Alkaloid-Inspired Urea-Containing Autophagy Inhibitor Shows Single-agent Anticancer Efficacy. J. Med. Chem., 2021, 64, 19, 14513–14525. 

Jen-Shin Song, Chih-Chun Chang, Chien-Huang Wu, Trinh Kieu Dinh, Jiing-Jyh Jan, Kuan-Wei Huang, Ming-Chen Chou, Ting-Yun Shiue, Kai-Chia Yeh, Yi-Yu Ke, Teng-Kuang Yeh, Yen-Nhi Ngoc Ta, Chia-Jui Lee, Jing-Kai Huang, Yun-Chieh Sung, Kak-Shan Shia* and Yunching Chen* (2021). A Highly Selective and Potent CXCR4 Antagonist for Hepatocellular Carcinoma Treatment.  Proc. Natl. Acad. Sci. U.S.A, 118 (13) e2015433118. 

Fang-Ying Wang, Yunching Chen, Yi-You Huang, Chao-Min Cheng (2021) Transdermal drug delivery systems for fighting common viral infectious diseases. Drug Delivery and Translational Research 11 (4), 1498-1508

Cheng-Ru Wu, Yi-Da Huang, Yong-Huei Hong, Ya-Hsin Liu, Manmath Narwane, Yu-Hsiang Chang, Trinh Kieu Dinh, Hsin-Tzu Hsieh, Yi-Jen Hseuh, Ping-Ching Wu, Chih-Wen Pao, Ting-Shan Chan, I-Jui Hsu, Yunching Chen, Hung-Chi Chen, Ting-Yu Chin, Tsai-Te Lu* (2021) Endogenous Conjugation of Biomimetic Dinitrosyl Iron Complex with Protein Vehicles for Oral Delivery of Nitric Oxide to Brain and Activation of Hippocampal Neurogenesis. JACS Au 2021, 1, 7, 998–1013

Anthony Yan‐Tang Wu, Yun‐Chieh Sung, Yen‐Ju Chen, Steven Ting‐Yu Chou, Vanessa Guo, Jasper Che‐Yung Chien, John Jun‐Sheng Ko, Alan Ling Yang, Hsi‐Chien Huang, Ju‐Chen Chuang, Syuan Wu, Meng‐Ru Ho, Maria Ericsson, Wan‐Wan Lin, Chantal Hoi Yin Cheung, Hsueh‐Fen Juan, Koji Ueda, Yunching Chen, Charles Pin‐Kuang Lai* (2020). Multiresolution Imaging Using Bioluminescence Resonance Energy Transfer Identifies Distinct Biodistribution Profiles of Extracellular Vesicles and Exomeres with Redirected Tropism. Adv Sci, 16;7(19):2001467. 

Chih-Chun Chang, Trinh Kieu Dinh, Yi-An Lee, Fu-Nien Wang, Yun-Chieh Sung, Pei-Lun Yu, Shao-Chieh Chiu, Yu-Chuan Shih, Cheng-Yun Wu, Yi-Da Huang, Jane Wang, Tsai-Te Lu, Dehui Wan, Yunching Chen* (2020). Nanoparticle Delivery of MnO2 and Antiangiogenic Therapy to Overcome Hypoxia-Driven Tumor Escape and Suppress Hepatocellular Carcinoma. ACS Appl. Mater. Interfaces, 12, 40, 44407–44419. 

Kuan-Wei Huang, Fu-Fei Hsu, Jiantai Timothy Qiu, Guann-Jen Chern, Yi-An Lee, Chih-Chun Chang1, Yu-Ting Huang, Yun-Chieh Sung, Cheng-Chin Chiang, Rui-Lin Huang, Chu-Chi Lin, Trinh Kieu Dinh, Hsi-Chien Huang, Yu-Chuan Shih, Donia Alson, Chun-Yen Lin, Yung-Chang Lin, Po-Chiao Chang, Shu-Yi Lin*, Yunching Chen* (2020). Highly Efficient and Tumor-Selective Nanoparticles for Dual-Targeted Immunogene Therapy against Cancer. Science Advances, 6(3), eaax5032. 

Yun-Chieh Sung, Pei-Ru Jin, Li-An Chu, Fu-Fei Hsu, Mei-Ren Wang, Chih-Chun Chang, Show-Jen Chiou, Jiantai Timothy Qiu, Dong-Yu Gao, Chu-Chi Lin, Yu-Sing Chen, Yi-Chiung Hsu, Jane Wang, Fu-Nien Wang, Pei-Lun Yu, Ann-Shyn Chiang,  Anthony Yan-Tang Wu, John Jun-Sheng Ko, Charles Pin-Kuang Lai, Tsai-Te Lu*, Yunching Chen* (2019). Delivery of Nitric Oxide with a Nanocarrier Promotes Tumour Vessel Normalization and Potentiates Anti-Cancer Therapies. Nature Nanotechnology, 14, 1160–1169.

Cin‐Hao Lin, Hsin‐Chuan Wen, Cheng‐Chin Chiang, Jen‐Sheng Huang, Yunching Chen, Sheng‐Kai Wang* (2019). Polyproline Tri‐Helix Macrocycles as Nanosized Scaffolds to Control Ligand Patterns for Selective Protein Oligomer Interactions. Small. 15(20).

Hung-Hsun Lu, Cheng-Hung Huang, Ting-Yun Shiue, Fu-Sheng Wang, Ko-Kai Chang, Yunching Chen, Chi-How Peng* (2019). Highly Efficient Gene Release in Spatiotemporal Precision Approached by Light and pH Dual Responsive Copolymers. Chemical Science. 10, 284-292. (IF=9.0)

Kuan-Wei Huang, Yu-Tsung Lai, Guann-Jen Chern, Shao-Feng Huang, Chia-Lung Tsai, Yun-Chieh Sung, Cheng-Chin Chiang, Pi-Bei Hwang, Ting-Lun Ho, Rui-Lin Huang, Ting-Yun Shiue, Yunching Chen*, and Sheng-Kai Wang* (2018). Galactose Derivative-Modified Nanoparticles for Efficient siRNA Delivery to Hepatocellular Carcinoma. Biomacromolecules. 19 (6), 2330–2339. (IF=5.8)

Chih-Chun Chang, Yang Yang, Dong-Yu Gao, Hui-Teng Cheng, Bryan Hoang, Po-Han Chao, Ling-Hsuan Chen, Joseph Bteich, Tsaiyu Chiang, Jia-Yu Liu, Shyh-Dar Li*, Yunching Chen* (2018). Docetaxel-carboxymethylcellulose nanoparticles ameliorate CCl4-induced hepatic fibrosis in Mice. Journal of Drug Targeting. 27:1-9. 

Yun-Chieh Sung, Ya-Chi Liu, Po-Han Chao, Chih-Chun Chang, Ts-Ting Lin, Ja-An Lin, Hui-Teng Cheng, Jane Wang, Charles P. Lai, Ling-Hsuan Chen, Peiru Jin, Anthony Y. Wu, Tsaiyu Chiang, Dong-Yu Gao, Dan G. Duda, Yunching Chen* (2018) Combined delivery of sorafenib and a MEK inhibitor using CXCR4-targeted nanoparticles reduces hepatic fibrosis and prevents tumor development. Theranostics. 8(4):894-905. 

Chun-Hung Liu, Guann-Gen Chern, Fu-Fei Hsu, Kuan-Wei Huang, Yun-Chieh Sung, Hsi-Chien Huang, Jiantai Timothy Qiu, Chu-Chi Lin, Chien-Hsun Wu, Han-Chung Wu, Jia-Yu Liu, Yunching Chen* (2018) A multifunctional nanocarrier for efficient TRAIL-based gene therapy against hepatocellular carcinoma with desmoplasia. Hepatology. 67(3):899-913. 

Yunching Chen*, Ya-Chi Liu, Yun-Chieh Sung, Rakesh R. Ramjiawan, Ts-Ting Lin, Chih-Chun Chang, Kuo-Shyang Jeng, Chiung-Fang Chang, Chun-Hung Liu, Dong-Yu Gao, Fu-Fei Hsu, Annique M. Duyverman, Shuji Kitahara, Peigen Huang, Simona Dima, Irinel Popescu, Keith T. Flaherty, Andrew X. Zhu, Nabeel Bardeesy, Rakesh K. Jain, Cyril H. Benes, and Dan G. Duda* (2017) Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors. Sci Rep. 7, 44123. 

Liying Wang, Yunching Chen, Hsin Yao Lin, Yung-Te Hou, Ling-Chu Yang, Aileen Y. Sun, Jia-Yu Liu, Chien-Wen Chang, and Dehui Wan (2017) Near-IR-Absorbing Gold Nanoframes with Enhanced Physiological Stability and Improved Biocompatibility for In Vivo Biomedical Applications. ACS Appl. Mater. Interfaces. 9 (4), 3873–3884. 

Ts-Ting Lin#, Dong-Yu Gao#, Ya-Chi Liu, Yun-Chieh Sung, Dehui Wan, Jia-Yu Liu, Tsaiyu Chiang, Liying Wang, Yunching Chen* (2016) Development and Characterization of Sorafenib-Loaded PLGA Nanoparticles for the Systemic Treatment of Liver Fibrosis. Journal of Controlled Release. 10, 211:62~70. 

Chun-Hung Liu#, Kun-Ming Chan#, Tsaiyu Chiang#, Jia-Yu Liu, Guann-Gen Chern, Fu-Fei Hsu, Yu-Hsuan Wu, Ya-Chi Liu, Yunching Chen*(2016) Dual-functional nanoparticles targeting CXCR4 and delivering anti-angiogenic siRNA ameliorate liver fibrosis. Molecular Pharmaceutics. 13 (7), 2253–2262. 

Chun-Jui Lin, Chen-Hsiang Kuan, Hsi-Chin Wu, Yunching Chen, Chien-Wen Chang, Jih-Yang Huang, Tzu-Wei Wang (2016) Dual Responsive Self-assembling Nanocarrier with Active Targeting Peptide Ligand for Orthotopic Ovarian Cancer Theranostics. Biomaterials. 90:12-26.  

Jia-Yu Liu, Tsaiyu Chiang, Chun-Hung Liu, Guann-Gen Chern, Ts-Ting Lin, Dong-Yu Gao, Yunching Chen* (2015) Delivery of siRNA using CXCR4-Targeted Nanoparticles Modulates Tumor Microenvironment and Achieves a Potent Anti-Tumor Response in Liver Cancer. Molecular Therapy. 23(11):1772-82. 

Dong-Yu Gao, Ts-Ting Lin, Yun-Chieh Sung, Ya Chi Liu, Wen-Hsuan Chiang, Chih-Chun Chang, Jia-Yu Liu, Yunching Chen* (2015) CXCR4-Targeted Lipid-Coated PLGA Nanoparticles Deliver Sorafenib and Overcome Acquired Drug Resistance in Liver Cancer. Biomaterials. 67: 194~203. 

Yunching Chen* & Dan G. Duda* (2015) Targeting immunosuppression after standard sorafenib treatment to facilitate immune checkpoint blockade in hepatocellular carcinoma – an auto-commentary on clinical potential and future development. Oncoimmunology. 27;4(10). 

Thomas Reiberger, Yunching Chen, Rakesh R. Ramjiawan, Tai Hato, Christopher Fan, Rekha Samuel, Sylvie Roberge, Peigen Huang, Gregory Y. Lauwers, Andrew X. Zhu, Nabeel Bardeesy, Rakesh K. Jain, Dan G. Duda (2015). An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis. Nature Protocol. 10: 1264–1274. 

Yunching Chen, Rakesh R. Ramjiawan, Thomas Reiberger, Mei Rosa Ng, Tai Hato, Yuhui Huang, Hiroki Ochiai, Elizabeth C. Unan, Teja P. Reddy, Peigen Huang, Andrew X. Zhu, Rakesh K. Jain, Dan G. Duda* (2015). CXCR4 inhibition in tumor microenvironment facilitates anti-PD-1 immunotherapy in sorafenib-treated HCC in mice. Hepatology, 61(5):1591-602. 

Hee-Sun Hana, Elisabeth Niemeyer, Yuhui Huang, Walid S. Kamoun, John D. Martin, Jayeeta Bhaumik, Yunching Chen, Sylvie Roberge, Jian Cui, Margaret R. Martin, Dai Fukumura, Rakesh K. Jain, Moungi G. Bawendi, and Dan G. Duda (2014). Novel quantum dot/antibody conjugates for in vivo cytometric imaging in mice. Proceedings of the National Academy of Sciences, 112(5):1350-5. 

Yunching Chen*, Dong-Yu Gao, Leaf Huang (2014). In Vivo Delivery of miRNAs For Cancer Therapy: Challenges and Strategies. Advanced Drug Delivery Reviews, 81:128–141. 

Yunching Chen, Yuhui Huang, Thomas Reiberger, Annique M. Duyverman, Peigen Huang, Rekha Samue, Lotte Hiddingh, Sylvie Roberge, Christina Koppel, Gregory Y. Lauwers, Andrew X. Zhu, Rakesh K. Jain, Dan G. Duda* (2014). Differential effects of sorafenib on liver versus tumor fibrosis mediated by SDF1α/CXCR4 axis and Gr-1+ myeloid cell infiltration in mice. Hepatology, 59(4):1435-47.